San Francisco overdose deaths fall 23% since peak of fentanyl crisis, lowest in 5 years

San Francisco’s accidental overdose deaths in 2025 fell 23.3% since the fentanyl crisis peaked, to the lowest level in at least five years, officials said.

A preliminary report by the Office of the Chief Medical Examiner showed 621 fatal accidental overdose cases in 2025, down from a high of 810 in 2023. It was the lowest number since 2020.