Cases of sexually transmitted diseases in San Francisco dramatically dropped in 2025 when compared to previous years, as reported this week by the city’s public health department.
Monday marked the start of Sexually Transmitted Infection Awareness Week at the San Francisco Department of Public Health and the office highlighted declines in common STI cases.
In 2025, San Francisco saw a 24% decrease in reported syphilis cases, an 18% decrease in chlamydia cases, and a 5% decrease in gonorrhea cases when compared to 2024. Public health officials believe the increased use of an antibiotic meant to prevent infection, doxycycline, contributed to the reductions.
“STI prevention is a key priority for SFDPH, and we are thrilled to see that doxy-PEP is making a difference in our communities,” said Director of Health Daniel Tsai. “STI Awareness Week reminds all of us just how important it is to pay attention to our sexual health and learn about the many effective prevention and treatment options that are available.”
The department reported the steepest declines were among men who have sex with men and transgender women. However, the department affirms disparities persist across the city.
Syphilis cases among females dropped by 5% while cases for males who have sex with males decreased by 27% in the same year-over-year timeframe. People experiencing homelessness and using drugs were also reported to be disproportionately affected by syphilis.
Black residents continue to be affected by chlamydia, gonorrhea, and syphilis at higher rates than other racial groups.
SFDPH has stated it is working with community groups to create a collaborative approach to address public health concerns. The agency encourages people to talk with their doctors and get regular testing.
For those without insurance, SFDPH said the San Francisco City Clinic can be an option. More information about the clinic is available online.